Protein thiyl radical reactions and product formation: a kinetic simulation
نویسندگان
چکیده
منابع مشابه
Protein thiyl radical reactions and product formation: a kinetic simulation
Protein thiyl radicals are important intermediates generated in redox processes of thiols and disulfides. Thiyl radicals efficiently react with glutathione and ascorbate, and the common notion is that these reactions serve to eliminate thiyl radicals before they can enter potentially hazardous processes. However, over the past years increasing evidence has been provided for rather efficient int...
متن کاملsimulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water
abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
Kinetic Studies of Some Free Radical Reactions
Kinetic and mechanistic studies on some characteristic freeradica1 reactions are reviewed briefly. The unimolecular rearrangements: RCMe2CH ÷ Me2CCH2R, fall into two classes. Class 1: R = R'C(O)O for which the 1,2—migration occurs via a 5—eenter cyclic transition state with considerable charge separation, [R'C02 Me2CCH2]*. Class 2: R = H2C=CH, Me3CC=0, C6H5, Me3CCsC, and CsN, for which migratio...
متن کاملSuperoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling.
An increase in production of reactive oxygen species resulting in a decrease in nitric oxide bioavailability in the endothelium contributes to many cardiovascular diseases, and these reactive oxygen species can oxidize cellular macromolecules. Protein thiols are critical reducing equivalents that maintain cellular redox state and are primary targets for oxidative modification. We demonstrate en...
متن کاملReactions of the protein radical in peroxide-treated myoglobin. Formation of a heme-protein cross-link.
Reaction of horse myoglobin with H2O2 oxidizes the iron to the ferryl (Fe(IV) = O) state and produces a protein radical that is rapidly dissipated by poorly understood mechanisms. As reported here, the reaction with H2O2 results in covalent binding of up to 18% of the prosthetic heme group to the protein. The chromophore of the protein-bound prosthetic group is very similar to that of heme itse...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2015
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2014.12.006